Tirzepatide for weight loss is one of the newest medication options for adults who struggle with weight. Unlike earlier options, it works on two hormones instead of one. In this guide, we explain what that means, how it compares to semaglutide and what to expect.
What Is Tirzepatide?
In short, tirzepatide is a once-weekly injection. Meanwhile, Eli Lilly sells brand-name tirzepatide for chronic weight management as Zepbound. The FDA approved it on November 8, 2023, for adults with obesity, or with overweight and at least one weight-related condition.
Also, adults should use it together with a reduced-calorie diet and more physical activity.
How Tirzepatide for Weight Loss Works
Specifically, tirzepatide activates two hormone receptors, GIP and GLP-1. Your gut releases both hormones after meals. Together, they help reduce appetite and food intake, so many people feel satisfied with smaller portions.
In the FDA’s summary, adults without diabetes on the highest dose lost an average of 18% of their body weight in the main trial. Of course, results vary from person to person.
Tirzepatide vs. Semaglutide
- Hormones: semaglutide acts on GLP-1, while tirzepatide acts on both GIP and GLP-1.
- Schedule: you take both as a once-weekly injection.
- Side effects: both most often cause stomach-related side effects.
However, neither one is right for everyone. Therefore, your provider compares your health history, goals and budget before suggesting an option. You can read more in our guide on how semaglutide works.
Tirzepatide for Weight Loss: Side Effects and Safety
Common side effects include nausea, diarrhea, vomiting, constipation, stomach discomfort and injection site reactions. In addition, tirzepatide has a boxed warning about thyroid C-cell tumors that appeared in rats. For that reason, people with a personal or family history of medullary thyroid cancer, or MEN 2, should not use it.
What to Expect at Allure
First, La’Shawnta Jackson, PA-C, reviews your health and goals. Next, if tirzepatide fits, the dose usually starts low and rises slowly. Finally, regular check-ins help adjust your plan. Visit our Tirzepatide page to learn more.
Frequently Asked Questions
Is tirzepatide stronger than semaglutide?
Studies differ, and so do people. Above all, your provider will explain which option may fit you best.
Are compounded versions FDA-approved?
No. The FDA has approved only brand-name products, so ask which version your plan uses.
Book a consultation at Allure Medical Weight Control & Wellness, 141 E Alessandro Blvd, Suite 10C-1, Riverside, CA 92508, or call 951-374-0127. Walk-ins are welcome Tuesday through Saturday.
This article is for general education and is not medical advice. Treatment eligibility is determined by a licensed provider after an evaluation, and individual results vary.