Retatrutide Weight Loss
Retatrutide Weight Loss in Riverside, CA: What to Know
As a new investigational medication, retatrutide is still being studied for obesity. At Allure Medical Weight Control & Wellness in Riverside, near Moreno Valley, we help you understand the research and also explore FDA-approved weight loss options you can start today.
Retatrutide is not FDA approved. It is currently available only through clinical research, so Allure does not prescribe it.
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The Basics
What Is Retatrutide?
First of all, retatrutide is an investigational once-weekly injection developed by Eli Lilly. It is often called a “triple agonist” because it acts on three hormone receptors: GLP-1, GIP and glucagon.
So far, it is being studied in large phase 3 clinical trials for adults with obesity or overweight and weight-related health conditions. Until the FDA reviews and approves it, retatrutide is not a prescription medication that clinics or pharmacies can legally provide.
The Three Pathways Retatrutide Targets
GLP-1
The same pathway targeted by semaglutide. It also helps with appetite, fullness and blood sugar.
GIP
Also targeted by tirzepatide. In addition, it is involved in insulin release and metabolic balance.
Glucagon
The new part. In other words, researchers are studying its role in energy use and how the body uses stored fat.
Side by Side
Retatrutide vs. Semaglutide vs. Tirzepatide
Here is how the investigational medication compares with the FDA-approved options available today, such as semaglutide and tirzepatide.
| Semaglutide | Tirzepatide | Retatrutide | |
|---|---|---|---|
| Targets | GLP-1 | GLP-1 + GIP | GLP-1 + GIP + glucagon |
| How often | Once a week | Once a week | Once a week (in trials) |
| FDA-approved brands | Wegovy®, Ozempic® | Zepbound®, Mounjaro® | None |
| Status | FDA approved | FDA approved | Investigational |
| At Allure | Available if eligible | Available if eligible | Not offered |
~28.3%
Average weight reduction at the highest dose (12 mg) after 80 weeks in the TRIUMPH-1 phase 3 trial
vs. 2.2% with placebo
Source: Eli Lilly topline results, May 2026. Also, lower doses showed smaller averages. However, these results have not been reviewed by the FDA. Individual results vary.
What the Research Shows
Retatrutide Clinical Trial Results
In fact, early phase 3 results for retatrutide have drawn a lot of attention. Still, clinical trial averages are not a promise, and more data are expected as additional trials are completed.
What researchers reported in TRIUMPH-1:
- Adults with obesity or overweight, as well as at least one weight-related condition, without diabetes
- Once-weekly doses of 4 mg, 9 mg or 12 mg, which were then increased gradually
- Side effects such as nausea, diarrhea, constipation and vomiting were the most common
- About 11% at the 12 mg dose stopped treatment due to side effects, vs. about 5% on placebo
Protect Your Health
Is It Safe to Buy Retatrutide Online?
No. Because retatrutide is not approved, any product sold outside a clinical trial has not been reviewed for safety, quality or correct dosing. In fact, Eli Lilly has stated that retatrutide is legally available only to participants in its clinical trials.
Similarly, the FDA has warned consumers about unapproved GLP-1 products sold online, including products with the wrong ingredients or doses. Read the FDA’s warning.
Red flags to watch for:
- Sold online as “research peptide” or “not for human use”
- No prescription, so no medical evaluation is required
- Shipped as a powder, so you mix it yourself
- Sold by a seller, but not by a licensed U.S. pharmacy
- Claims to be “FDA approved” retatrutide
Interested in research? If so, you can search for enrolling retatrutide studies on ClinicalTrials.gov.
Available Today
FDA-Approved Weight Loss Options at Allure
So you do not have to wait for retatrutide. Instead, your provider can review whether one of these options fits your health and goals.
Semaglutide
An FDA-approved GLP-1 medication (Wegovy®), especially for chronic weight management in eligible adults.
Tirzepatide
An FDA-approved GLP-1 + GIP medication (Zepbound®), also for chronic weight management in eligible adults.
Medical Weight Loss Program
Provider-guided plans, as well as nutrition, activity and progress check-ins.
Patient Reviews
Why Patients Choose Allure
Patients especially value our friendly staff and personalized attention, although individual results vary.
Near You
Medical Weight Loss Near Riverside & Moreno Valley
Allure Medical Weight Control & Wellness
141 E Alessandro Blvd, Suite 10C-1
Riverside, CA 92508
Just minutes from Moreno Valley, we also welcome patients from Riverside, Perris, Corona, Jurupa Valley, Loma Linda and across the Inland Empire. Walk-ins are also welcome Tuesday through Saturday.
Related Services
Questions
Retatrutide FAQs
Is retatrutide FDA approved?
No. Retatrutide is an investigational medication that is still being studied in clinical trials. It has not been approved by the FDA for weight loss or any other use.
Does Allure offer retatrutide in Riverside?
No. Allure does not prescribe retatrutide. We offer medically supervised programs with FDA-approved options, such as semaglutide and tirzepatide, for patients who qualify.
When will retatrutide be available?
No approval date has been set. Eli Lilly is completing its phase 3 trials, and the FDA must review the results before retatrutide could be prescribed. Timelines can change.
How is retatrutide different from semaglutide and tirzepatide?
Semaglutide targets GLP-1. Tirzepatide targets GLP-1 and GIP. Retatrutide targets GLP-1, GIP and glucagon, which is why it is called a triple agonist.
How much weight did people lose on retatrutide?
In the TRIUMPH-1 phase 3 trial, people on the highest dose lost about 28% of their body weight on average after 80 weeks, compared with about 2% on placebo, according to Eli Lilly. Results vary and have not been reviewed by the FDA.
What are the side effects of retatrutide?
In trials, the most common side effects were digestive, including nausea, diarrhea, constipation and vomiting. They were more common at higher doses.
Is it safe to buy retatrutide online or as a research peptide?
No. Products sold online as research peptides are not approved, and their ingredients, purity and dose are unknown. Do not inject products that are labeled not for human use.
Can I join a retatrutide clinical trial?
Possibly. You can search for studies that are enrolling on ClinicalTrials.gov and talk with your primary care provider about whether a trial is right for you.
What can I do while I wait for retatrutide?
Schedule a consultation. Your provider can review your health history and discuss whether an FDA-approved medication or a medical weight loss program is right for you now.